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Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10). Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.
Optimal dilution of the Cytokeratin 1 antibody should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the Cytokeratin 1 antibody.
Aliquot the Cytokeratin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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